Interactions médicamenteuses
Meperidine + Olanzapine / samidorphan
Gravité: Contre-indiquée
Meperidine and Olanzapine / samidorphan: contraindicated interaction.
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Résumé
Samidorphan is an opioid antagonist that blocks the effect of meperidine and can precipitate acute withdrawal in opioid-dependent patients. The combination is contraindicated in patients using opioids.
Ce que signifie cette interaction, en termes simples
Meperidine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Samidorphan is a mu-opioid receptor antagonist that opposes the pharmacologic effects of opioid agonists.
Conduite à tenir
Do not start olanzapine/samidorphan until the patient has been opioid-free for at least 7 days for short-acting opioids. Choose another antipsychotic if ongoing opioid therapy is needed.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Meperidine
- Alvimopan + Meperidine Contre-indiquée
- Isocarboxazid + Meperidine Contre-indiquée
- Meperidine + Methylene blue Contre-indiquée
- Meperidine + Phenelzine Contre-indiquée
- Meperidine + Procarbazine Contre-indiquée
- Meperidine + Rasagiline Contre-indiquée
Questions fréquentes
Can I take Meperidine with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Meperidine and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan is an opioid antagonist that blocks the effect of meperidine and can precipitate acute withdrawal in opioid-dependent patients. The combination is contraindicated in patients using opioids.
How serious is the interaction between Meperidine and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start olanzapine/samidorphan until the patient has been opioid-free for at least 7 days for short-acting opioids. Choose another antipsychotic if ongoing opioid therapy is needed.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
