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Interactions médicamenteuses

Meperidine + Phenelzine

Gravité: Contre-indiquée

Meperidine and Phenelzine: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Combining an irreversible MAO inhibitor with meperidine can cause severe, potentially fatal reactions, including serotonin syndrome with hyperthermia, rigidity, agitation and coma, and in some cases severe hypertension or respiratory depression. The combination is contraindicated in labeling.

Ce que signifie cette interaction, en termes simples

Meperidine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Meperidine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Phenelzine irreversibly inhibits MAO, and meperidine blocks serotonin reuptake, producing excessive serotonergic activity.

Conduite à tenir

Do not use together. Avoid meperidine for at least 14 days after stopping phenelzine and choose a safer opioid such as morphine with caution.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Meperidine with Phenelzine?

MediHelp rates the interaction as contraindicated. Meperidine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an irreversible MAO inhibitor with meperidine can cause severe, potentially fatal reactions, including serotonin syndrome with hyperthermia, rigidity, agitation and coma, and in some cases severe hypertension or respiratory depression. The combination is contraindicated in labeling.

How serious is the interaction between Meperidine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Avoid meperidine for at least 14 days after stopping phenelzine and choose a safer opioid such as morphine with caution.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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