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Interactions médicamenteuses

Meperidine + Rasagiline

Gravité: Contre-indiquée

Meperidine and Rasagiline: contraindicated interaction.

Dernière mise à jour

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Résumé

Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.

Ce que signifie cette interaction, en termes simples

Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Meperidine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with meperidine's serotonin reuptake inhibition increases serotonergic activity.

Conduite à tenir

Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Meperidine with Rasagiline?

MediHelp rates the interaction as contraindicated. Meperidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline labeling warns against meperidine because of reports of serious, sometimes fatal serotonin syndrome-like reactions with MAO inhibitors. Symptoms can include agitation, hyperthermia, rigidity and autonomic instability.

How serious is the interaction between Meperidine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow an adequate washout interval, generally at least 14 days after rasagiline. Use a different analgesic.

What other medicines interact with Meperidine?

MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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