Interactions médicamenteuses
Methimazole + Phenindione
Gravité: Modérée
Methimazole and Phenindione: moderate interaction.
Dernière mise à jour
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Résumé
Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
Ce que signifie cette interaction, en termes simples
Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Normalization of thyroid state reduces clotting factor turnover, which diminishes the response to vitamin K antagonists.
Conduite à tenir
Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Methimazole
- Carbamazepine + Methimazole Majeure
- Clozapine + Methimazole Majeure
- Methimazole + Propylthiouracil Majeure
- Methimazole + Sodium iodide i-131 Majeure
- Iodinated glycerol + Methimazole Modérée
- Iodine + Methimazole Modérée
Questions fréquentes
Can I take Methimazole with Phenindione?
MediHelp rates the interaction as moderate. Methimazole and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Correcting hyperthyroidism with methimazole slows the catabolism of vitamin K-dependent clotting factors. As a result the anticoagulant effect of vitamin K antagonists such as phenindione tends to fall as the patient becomes euthyroid. Starting or stopping methimazole can therefore change INR control.
How serious is the interaction between Methimazole and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when methimazole is started, changed or stopped. Adjust the phenindione dose to maintain the target INR.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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