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Interactions médicamenteuses

Miconazole + Simvastatin

Gravité: Majeure

Miconazole and Simvastatin: major interaction.

Dernière mise à jour

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Résumé

Systemic miconazole can increase simvastatin exposure and the risk of myopathy and rhabdomyolysis. Vaginal absorption is limited, but caution is warranted given the narrow safety margin.

Ce que signifie cette interaction, en termes simples

Miconazole and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Miconazole belongs to Anti Fungals; Simvastatin belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Miconazole inhibits CYP3A4 metabolism of simvastatin.

Conduite à tenir

Avoid with oral or buccal miconazole; withhold simvastatin during therapy. With vaginal use, monitor for muscle symptoms or use a non-CYP3A4 statin temporarily.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Miconazole with Simvastatin?

MediHelp rates the interaction as major. Miconazole and Simvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic miconazole can increase simvastatin exposure and the risk of myopathy and rhabdomyolysis. Vaginal absorption is limited, but caution is warranted given the narrow safety margin.

How serious is the interaction between Miconazole and Simvastatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral or buccal miconazole; withhold simvastatin during therapy. With vaginal use, monitor for muscle symptoms or use a non-CYP3A4 statin temporarily.

What other medicines interact with Miconazole?

MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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