Interactions médicamenteuses
Mycophenolic acid + Valacyclovir
Gravité: Modérée
Mycophenolic acid and Valacyclovir: moderate interaction.
Dernière mise à jour
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Résumé
Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
Ce que signifie cette interaction, en termes simples
Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolic acid belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.
Pourquoi elle survient
Competition between acyclovir and MPA glucuronide for renal tubular secretion.
Conduite à tenir
Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Mycophenolic acid
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- Imipenem / cilastatin + Valacyclovir Modérée
Questions fréquentes
Can I take Mycophenolic acid with Valacyclovir?
MediHelp rates the interaction as moderate. Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.
How serious is the interaction between Mycophenolic acid and Valacyclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
