Interactions médicamenteuses
Azathioprine + Mycophenolic acid
Gravité: Majeure
Azathioprine and Mycophenolic acid: major interaction.
Dernière mise à jour
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Résumé
Both inhibit purine synthesis pathways and together can cause additive bone marrow suppression, with leukopenia and increased infection risk. Combination offers no established benefit.
Ce que signifie cette interaction, en termes simples
Azathioprine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Mycophenolic acid belongs to Miscellaneous.
Pourquoi elle survient
Additive inhibition of purine metabolism in lymphocytes and marrow cells.
Conduite à tenir
Avoid the combination; use one agent only. If a switch is made, monitor complete blood counts.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Mycophenolic acid
Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Bcg vaccine live Contre-indiquée
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- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
Questions fréquentes
Can I take Azathioprine with Mycophenolic acid?
MediHelp rates the interaction as major. Azathioprine and Mycophenolic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both inhibit purine synthesis pathways and together can cause additive bone marrow suppression, with leukopenia and increased infection risk. Combination offers no established benefit.
How serious is the interaction between Azathioprine and Mycophenolic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use one agent only. If a switch is made, monitor complete blood counts.
What other medicines interact with Mycophenolic acid?
MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Cholestyramine, Ganciclovir. The full list is on the Mycophenolic acid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
