Interactions médicamenteuses
Nelarabine + Tofacitinib
Gravité: Majeure
Nelarabine and Tofacitinib: major interaction.
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Résumé
Nelarabine is a cytotoxic, immunosuppressive and myelosuppressive agent, and combining it with tofacitinib adds to the risk of serious infection and cytopenias. Neurotoxicity from nelarabine remains a separate concern.
Ce que signifie cette interaction, en termes simples
Nelarabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nelarabine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Pourquoi elle survient
Additive immunosuppression and myelosuppression from JAK inhibition plus cytotoxic purine analog therapy.
Conduite à tenir
Avoid concurrent use where possible and hold tofacitinib during cytotoxic chemotherapy. If used together, monitor blood counts and signs of infection closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Tofacitinib
- Baricitinib + Tofacitinib Contre-indiquée
- Cladribine + Tofacitinib Contre-indiquée
- Tofacitinib + Upadacitinib Contre-indiquée
- Abatacept + Tofacitinib Majeure
- Anti-thymocyte + Tofacitinib Majeure
- Antithymocyte globulin equine + Tofacitinib Majeure
Autres interactions de Nelarabine
- Deferiprone + Nelarabine Majeure
- Nelarabine + Pentostatin Majeure
- Nelarabine + Siponimod Majeure
- Denosumab + Nelarabine Modérée
- Fingolimod + Nelarabine Modérée
- Hydroxyurea + Nelarabine Modérée
Questions fréquentes
Can I take Nelarabine with Tofacitinib?
MediHelp rates the interaction as major. Nelarabine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelarabine is a cytotoxic, immunosuppressive and myelosuppressive agent, and combining it with tofacitinib adds to the risk of serious infection and cytopenias. Neurotoxicity from nelarabine remains a separate concern.
How serious is the interaction between Nelarabine and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and hold tofacitinib during cytotoxic chemotherapy. If used together, monitor blood counts and signs of infection closely.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
