Interactions médicamenteuses
Deferiprone + Nelarabine
Gravité: Majeure
Deferiprone and Nelarabine: major interaction.
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Résumé
Nelarabine causes myelosuppression including neutropenia, in addition to its neurotoxicity. With deferiprone, severe neutropenia may be more likely.
Ce que signifie cette interaction, en termes simples
Deferiprone and Nelarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Nelarabine belongs to Oncology.
Pourquoi elle survient
Additive myelosuppression.
Conduite à tenir
Avoid the combination if possible; otherwise monitor absolute neutrophil count frequently and withhold deferiprone if neutropenia occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Deferiprone
- Clozapine + Deferiprone Contre-indiquée
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
Autres interactions de Nelarabine
- Nelarabine + Pentostatin Majeure
- Nelarabine + Siponimod Majeure
- Nelarabine + Tofacitinib Majeure
- Denosumab + Nelarabine Modérée
- Fingolimod + Nelarabine Modérée
- Hydroxyurea + Nelarabine Modérée
Questions fréquentes
Can I take Deferiprone with Nelarabine?
MediHelp rates the interaction as major. Deferiprone and Nelarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelarabine causes myelosuppression including neutropenia, in addition to its neurotoxicity. With deferiprone, severe neutropenia may be more likely.
How serious is the interaction between Deferiprone and Nelarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor absolute neutrophil count frequently and withhold deferiprone if neutropenia occurs.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
