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Interactions médicamenteuses

Nitroglycerin rectal + Vardenafil

Gravité: Contre-indiquée

Nitroglycerin rectal and Vardenafil: contraindicated interaction.

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Résumé

Vardenafil potentiates the hypotensive effect of rectal nitroglycerin. The combination can cause dangerous drops in blood pressure.

Ce que signifie cette interaction, en termes simples

Nitroglycerin rectal and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Niveau de preuve: High

Pourquoi elle survient

Additive cGMP-mediated vasodilation from nitrate-derived nitric oxide and PDE5 inhibition.

Conduite à tenir

Avoid combination; separate by at least 24 hours. Use non-nitrate therapy if treatment is needed soon after vardenafil.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Nitroglycerin rectal with Vardenafil?

MediHelp rates the interaction as contraindicated. Nitroglycerin rectal and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil potentiates the hypotensive effect of rectal nitroglycerin. The combination can cause dangerous drops in blood pressure.

How serious is the interaction between Nitroglycerin rectal and Vardenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination; separate by at least 24 hours. Use non-nitrate therapy if treatment is needed soon after vardenafil.

What other medicines interact with Vardenafil?

MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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