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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Isosorbide mononitrate + Vardenafil

Gravité: Contre-indiquée

Isosorbide mononitrate and Vardenafil: contraindicated interaction.

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Résumé

Vardenafil inhibits PDE5 and isosorbide mononitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.

Ce que signifie cette interaction, en termes simples

Isosorbide mononitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isosorbide mononitrate belongs to Cardiovascular; Vardenafil belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

PDE5 inhibition potentiates nitrate-induced cGMP vasodilation

Conduite à tenir

Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isosorbide mononitrate with Vardenafil?

MediHelp rates the interaction as contraindicated. Isosorbide mononitrate and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil inhibits PDE5 and isosorbide mononitrate releases nitric oxide, together causing a large rise in cGMP in vascular smooth muscle. Profound, sometimes fatal, hypotension and myocardial ischaemia may result.

How serious is the interaction between Isosorbide mononitrate and Vardenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; do not give a nitrate within 24 hours of vardenafil, and use an alternative if both are required.

What other medicines interact with Vardenafil?

MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.

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