Interactions médicamenteuses
Amyl nitrite + Vardenafil
Gravité: Contre-indiquée
Amyl nitrite and Vardenafil: contraindicated interaction.
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Résumé
Vardenafil greatly enhances the vasodilator effect of nitrates such as amyl nitrite. This can cause severe, potentially fatal hypotension.
Ce que signifie cette interaction, en termes simples
Amyl nitrite and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Nitrates increase cGMP through nitric oxide and vardenafil inhibits its degradation by PDE5, causing excessive vasodilation.
Conduite à tenir
Do not co-administer, including recreational nitrite inhalants. Keep a safe interval, at least 24 hours, before any nitrate is given after vardenafil.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Vardenafil
- Glyceryl trinitrate pr + Vardenafil Contre-indiquée
- Isosorbide dinitrate + Vardenafil Contre-indiquée
- Isosorbide mononitrate + Vardenafil Contre-indiquée
- Nicorandil + Vardenafil Contre-indiquée
- Nitroglycerin po + Vardenafil Contre-indiquée
- Nitroglycerin rectal + Vardenafil Contre-indiquée
Questions fréquentes
Can I take Amyl nitrite with Vardenafil?
MediHelp rates the interaction as contraindicated. Amyl nitrite and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil greatly enhances the vasodilator effect of nitrates such as amyl nitrite. This can cause severe, potentially fatal hypotension.
How serious is the interaction between Amyl nitrite and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, including recreational nitrite inhalants. Keep a safe interval, at least 24 hours, before any nitrate is given after vardenafil.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Glyceryl trinitrate pr, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Vardenafil page.
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