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Interactions médicamenteuses

Dexamethasone + Nivolumab

Gravité: Modérée

Dexamethasone and Nivolumab: moderate interaction.

Dernière mise à jour

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Résumé

Corticosteroids can blunt the immune activation on which nivolumab depends, though they are also the standard treatment for immune-related adverse events. Use at physiological doses or for managing toxicity is acceptable, whereas high-dose prophylactic or prolonged use may reduce efficacy.

Ce que signifie cette interaction, en termes simples

Dexamethasone and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Dexamethasone belongs to Endocrine; Nivolumab belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Pharmacodynamic antagonism: glucocorticoid immunosuppression opposes T-cell mediated antitumor activity enabled by PD-1 blockade.

Conduite à tenir

Avoid unnecessary corticosteroids before or during nivolumab. Use dexamethasone when needed for immune-related adverse events or supportive care at the lowest effective dose.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dexamethasone with Nivolumab?

MediHelp rates the interaction as moderate. Dexamethasone and Nivolumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can blunt the immune activation on which nivolumab depends, though they are also the standard treatment for immune-related adverse events. Use at physiological doses or for managing toxicity is acceptable, whereas high-dose prophylactic or prolonged use may reduce efficacy.

How serious is the interaction between Dexamethasone and Nivolumab?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary corticosteroids before or during nivolumab. Use dexamethasone when needed for immune-related adverse events or supportive care at the lowest effective dose.

What other medicines interact with Dexamethasone?

MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Rilpivirine. The full list is on the Dexamethasone page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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