Drug interactions
Phenelzine + Trimipramine
Severity: Contraindicated
Phenelzine and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.
What this interaction means in plain words
Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with tricyclic reuptake inhibition causes excess serotonergic and noradrenergic activity.
What to do
Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Pimozide + Trimipramine Contraindicated
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Phenelzine with Trimipramine?
MediHelp rates the interaction as contraindicated. Phenelzine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with a nonselective MAOI can cause serotonin syndrome and hypertensive crisis. Reactions can be severe and life-threatening.
How serious is the interaction between Phenelzine and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow a washout of at least 14 days after stopping phenelzine before trimipramine, and an appropriate interval in the other direction.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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