Interactions médicamenteuses
Folic acid + Pyrimethamine
Gravité: Modérée
Folic acid and Pyrimethamine: moderate interaction.
Dernière mise à jour
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Résumé
Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
Ce que signifie cette interaction, en termes simples
Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
Pourquoi elle survient
Pharmacodynamic antagonism, as folic acid supplies the folate end-product whose synthesis pyrimethamine blocks.
Conduite à tenir
Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Pyrimethamine
- Deferiprone + Pyrimethamine Majeure
- Eliglustat + Pyrimethamine Majeure
- Acalabrutinib + Pyrimethamine Modérée
- Brexpiprazole + Pyrimethamine Modérée
- Dapsone + Pyrimethamine Modérée
- Fosphenytoin + Pyrimethamine Modérée
Autres interactions de Folic acid
- Ethotoin + Folic acid Modérée
- Folic acid + Fosphenytoin Modérée
- Folic acid + Glucarpidase Modérée
- Folic acid + Methotrexate Modérée
- Folic acid + Pafolacianine Modérée
- Folic acid + Phenobarbital Modérée
Questions fréquentes
Can I take Folic acid with Pyrimethamine?
MediHelp rates the interaction as moderate. Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
How serious is the interaction between Folic acid and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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