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Interactions médicamenteuses

Talimogene laherparepvec + Valganciclovir

Gravité: Majeure

Talimogene laherparepvec and Valganciclovir: major interaction.

Dernière mise à jour

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Résumé

Talimogene laherparepvec is a live, attenuated herpes simplex virus that depends on replication. Valganciclovir is converted to ganciclovir, which is active against herpes viruses and may reduce the efficacy of the oncolytic virus.

Ce que signifie cette interaction, en termes simples

Talimogene laherparepvec and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Talimogene laherparepvec belongs to Oncology; Valganciclovir belongs to Anti Virals.

Niveau de preuve: Low

Pourquoi elle survient

Antiviral inhibition of viral DNA replication, which may blunt the live oncolytic virus.

Conduite à tenir

Avoid antiherpetic antivirals during talimogene therapy where possible. If treatment of a herpetic infection is required, treat it and reassess the oncolytic regimen.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Talimogene laherparepvec with Valganciclovir?

MediHelp rates the interaction as major. Talimogene laherparepvec and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Talimogene laherparepvec is a live, attenuated herpes simplex virus that depends on replication. Valganciclovir is converted to ganciclovir, which is active against herpes viruses and may reduce the efficacy of the oncolytic virus.

How serious is the interaction between Talimogene laherparepvec and Valganciclovir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antiherpetic antivirals during talimogene therapy where possible. If treatment of a herpetic infection is required, treat it and reassess the oncolytic regimen.

What other medicines interact with Valganciclovir?

MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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