Interactions médicamenteuses
Probenecid + Valganciclovir
Gravité: Majeure
Probenecid and Valganciclovir: major interaction.
Dernière mise à jour
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Résumé
Probenecid decreases the renal clearance of ganciclovir, the active form of valganciclovir, and increases systemic exposure. This raises the risk of ganciclovir toxicity, notably myelosuppression and neurotoxicity including seizures.
Ce que signifie cette interaction, en termes simples
Probenecid and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Probenecid belongs to Genitourinary; Valganciclovir belongs to Anti Virals.
Pourquoi elle survient
Probenecid inhibits renal tubular secretion of ganciclovir via organic anion transporters.
Conduite à tenir
Avoid the combination where possible; if used, monitor complete blood counts and neurologic status and consider reducing the valganciclovir dose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Probenecid
- Ketorolac intranasal + Probenecid Contre-indiquée
- Ketorolac + Probenecid Contre-indiquée
- Baricitinib + Probenecid Majeure
- Ceftazidime / avibactam + Probenecid Majeure
- Methotrexate + Probenecid Majeure
- Pralatrexate + Probenecid Majeure
Autres interactions de Valganciclovir
Questions fréquentes
Can I take Probenecid with Valganciclovir?
MediHelp rates the interaction as major. Probenecid and Valganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Probenecid decreases the renal clearance of ganciclovir, the active form of valganciclovir, and increases systemic exposure. This raises the risk of ganciclovir toxicity, notably myelosuppression and neurotoxicity including seizures.
How serious is the interaction between Probenecid and Valganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor complete blood counts and neurologic status and consider reducing the valganciclovir dose.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
