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Interactions médicamenteuses

Ifosfamide + Talimogene laherparepvec

Gravité: Contre-indiquée

Ifosfamide and Talimogene laherparepvec: contraindicated interaction.

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Résumé

Talimogene laherparepvec is a live, modified herpes simplex virus that replicates in tissue. In patients immunosuppressed by ifosfamide, this could lead to disseminated or serious herpetic infection.

Ce que signifie cette interaction, en termes simples

Ifosfamide and Talimogene laherparepvec are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ifosfamide belongs to Oncology; Talimogene laherparepvec belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Immunosuppression from chemotherapy impairs control of the replicating oncolytic herpes virus.

Conduite à tenir

Do not give talimogene laherparepvec to patients receiving ifosfamide or otherwise immunocompromised. Choose an alternative therapy and consult the oncology team.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ifosfamide with Talimogene laherparepvec?

MediHelp rates the interaction as contraindicated. Ifosfamide and Talimogene laherparepvec are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Talimogene laherparepvec is a live, modified herpes simplex virus that replicates in tissue. In patients immunosuppressed by ifosfamide, this could lead to disseminated or serious herpetic infection.

How serious is the interaction between Ifosfamide and Talimogene laherparepvec?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give talimogene laherparepvec to patients receiving ifosfamide or otherwise immunocompromised. Choose an alternative therapy and consult the oncology team.

What other medicines interact with Ifosfamide?

MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.

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