दवा संदर्भ
Thalidomide
Thalidomide is a medicine in the class miscellaneous. It is used for multiple myeloma.
- दवा वर्ग: Miscellaneous
- उपयोग: multiple myeloma
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Miscellaneous
- ATC कोड
- L04AX02
- सामान्य रूप
- कैप्सूल
- ज्ञात अंतःक्रियाएँ
- 41 (गंभीर: 9 · मध्यम: 29 · हल्की: 3)
- ब्रांड नाम
- 3
- देश और बाज़ार
- 2
उपयोग
यह कैसे काम करती है
Mechanism not fully understood. Acts through cereblon, a component of a cullin ring E3 ubiquitin ligase complex; has immunomodulatory, anti-inflammatory and antiangiogenic properties.
वयस्कों की सामान्य खुराक (लेबल सारांश)
Newly diagnosed multiple myeloma (with dexamethasone): 200 mg orally once daily in 28-day cycles, with water, preferably at bedtime and at least 1 hour after the evening meal; dexamethasone 40 mg daily on days 1-4, 9-12 and 17-20 every 28 days
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unsafe Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms.
- स्तनपान
- Unsafe No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
रिपोर्ट किए गए दुष्प्रभाव
- Fatigue
- Hypocalcemia
- Edema
- Constipation
- Sensory neuropathy
- Dyspnea
बॉक्स्ड चेतावनियाँ
- Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule. Must never be used by females who are or could become pregnant. Exclude pregnancy before treatment and use two reliable contraception methods. Available only through the THALOMID REMS program.
प्रतिसंकेत
- Pregnancy
- Demonstrated hypersensitivity to the drug or its components
किन्हें सावधानी रखनी चाहिए
- Venous and arterial thromboembolism, including ischemic heart disease, MI and stroke, with dexamethasone
- Increased mortality when pembrolizumab is added to a thalidomide analogue plus dexamethasone in MM; not recommended outside controlled trials
- Frequent drowsiness and somnolence; avoid hazardous tasks and other sedating drugs
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (41)
- Bortezomib + Thalidomide Major
- Carbamazepine + Thalidomide Major
- Griseofulvin + Thalidomide Major
- Modafinil + Thalidomide Major
- Nivolumab + Thalidomide Major
- Phenytoin + Thalidomide Major
- Rifabutin + Thalidomide Major
- Rifampicin + Thalidomide Major
- Thalidomide + Vincristine Major
- Amiodarone + Thalidomide Moderate
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Thalidomide का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
इसी वर्ग की अन्य दवाएँ
अक्सर पूछे जाने वाले प्रश्न
What is Thalidomide used for?
Thalidomide is a medicine in the class miscellaneous. It is used for Multiple myeloma.
What side effects have been reported with Thalidomide?
Fatigue, Hypocalcemia, Edema, Constipation, Sensory neuropathy, Dyspnea. Serious warning: Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule.
Can Thalidomide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms. Breastfeeding: Unsafe. No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
What does Thalidomide interact with?
MediHelp lists 41 known interactions for Thalidomide. Major: 9 · Moderate: 29 · Minor: 3. The most serious include Bortezomib, Carbamazepine, Griseofulvin.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
