दवा संदर्भ
Zoledronic acid
Zoledronic acid is a medicine in the class musculoskeletal. It is used for glucocorticoid-induced osteoporosis.
- दवा वर्ग: Musculoskeletal
- उपयोग: glucocorticoid-induced osteoporosis
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
मुख्य तथ्य
- दवा वर्ग
- Musculoskeletal
- ATC कोड
- M05BA08
- सामान्य रूप
- इंजेक्शन, इन्फ्यूज़न
- सामान्य मात्राएँ
- 4 mg/5 ml, 5 mg/100 ml, 4 mg
- ज्ञात अंतःक्रियाएँ
- 19 (मध्यम: 13 · हल्की: 6)
- ब्रांड नाम
- 37
- देश और बाज़ार
- 5
उपयोग
यह कैसे काम करती है
Bisphosphonate; inhibits bone resorption via actions on osteoclast activity, leading to indirect increase in bone density
वयस्कों की सामान्य खुराक (लेबल सारांश)
Hypercalcemia of Malignancy (Zometa): No more than 4 mg IV (infused over >15 minutes) once; may be repeated in 7 days
गर्भावस्था और स्तनपान
- गर्भावस्था
- Unsafe No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised.
- स्तनपान
- Unknown No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
रिपोर्ट किए गए दुष्प्रभाव
- Fatigue
- Vomiting
- Nausea
- Constipation
- Anemia
- Bone pain
प्रतिसंकेत
- Pregnancy
- All indications: Hypersensitivity, including rare cases of urticaria, angioedema, and anaphylactic reaction or shock
- Nononcologic uses: Hypocalcemia, severe renal impairment (CrCl <35 mL/min or evidence of acute renal impairment)
किन्हें सावधानी रखनी चाहिए
- Infuse over ≥15 minutes; faster infusion increases renal toxicity
- Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated with IV bisphosphonates
- Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates
गर्भावस्था या स्तनपान, किडनी या लिवर के रोग, एलर्जी और आप जो भी अन्य दवा या सप्लीमेंट लेते हैं, उसके बारे में अपने फार्मासिस्ट या डॉक्टर को बताएँ।
मुख्य इंटरैक्शन (19)
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
- Indomethacin + Zoledronic acid Moderate
- Sodium sulfate / ?magnesium sulfate / potassium chloride + Zoledronic acid Moderate
- Sodium sulfate / potassium sulfate / magnesium sulfate + Zoledronic acid Moderate
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Zoledronic acid का पूरा मोनोग्राफ खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें: खुराक, गर्भावस्था और स्तनपान, दुष्प्रभाव, चेतावनियाँ और सभी इंटरैक्शन।
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
इसी वर्ग की अन्य दवाएँ
संबंधित त्वरित पठन
अक्सर पूछे जाने वाले प्रश्न
What is Zoledronic acid used for?
Zoledronic acid is a medicine in the class musculoskeletal. It is used for Glucocorticoid-induced osteoporosis, Hypercalcemia of malignancy, Osteoporosis, Paget's disease.
What side effects have been reported with Zoledronic acid?
Fatigue, Vomiting, Nausea, Constipation, Anemia, Bone pain.
Can Zoledronic acid be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised. Breastfeeding: Unknown. No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
What does Zoledronic acid interact with?
MediHelp lists 19 known interactions for Zoledronic acid. Moderate: 13 · Minor: 6. The most serious include Amikacin, Bumetanide, Dichlorphenamide.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
