दवाओं की अंतःक्रिया
Astemizole + Clarithromycin
गंभीरता: निषिद्ध
Astemizole and Clarithromycin: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Clarithromycin raises astemizole concentrations and, together with the intrinsic QT effect of both drugs, may cause torsades de pointes and sudden death. The combination is contraindicated. Astemizole has been withdrawn in many markets, so the interaction is mainly of historical relevance.
इस इंटरैक्शन का सरल भाषा में अर्थ
Astemizole and Clarithromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Clarithromycin inhibits CYP3A4-mediated metabolism of astemizole and also prolongs QT through IKr blockade, giving pharmacokinetic and pharmacodynamic synergy.
क्या करें
Do not combine. Use a non-sedating antihistamine without QT liability, such as fexofenadine, loratadine or cetirizine.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Astemizole और Clarithromycin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Clarithromycin के अन्य इंटरैक्शन
- Avanafil + Clarithromycin निषिद्ध
- Cisapride + Clarithromycin निषिद्ध
- Clarithromycin + Colchicine निषिद्ध
- Clarithromycin + Conivaptan निषिद्ध
- Clarithromycin + Dihydroergotamine निषिद्ध
- Clarithromycin + Dihydroergotamine intranasal निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Astemizole with Clarithromycin?
MediHelp rates the interaction as contraindicated. Astemizole and Clarithromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin raises astemizole concentrations and, together with the intrinsic QT effect of both drugs, may cause torsades de pointes and sudden death. The combination is contraindicated. Astemizole has been withdrawn in many markets, so the interaction is mainly of historical relevance.
How serious is the interaction between Astemizole and Clarithromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-sedating antihistamine without QT liability, such as fexofenadine, loratadine or cetirizine.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Avanafil, Cisapride, Colchicine. The full list is on the Clarithromycin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
