दवाओं की अंतःक्रिया
Clarithromycin + Colchicine
गंभीरता: निषिद्ध
Clarithromycin and Colchicine: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Clarithromycin markedly increases colchicine exposure, and fatal colchicine toxicity has been reported with this combination. Presentations include severe gastrointestinal symptoms, myopathy, bone marrow suppression, multiorgan failure and death. Patients with renal or hepatic impairment and older adults are at greatest risk, but toxicity can occur even at standard colchicine doses.
इस इंटरैक्शन का सरल भाषा में अर्थ
Clarithromycin and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Colchicine belongs to Genitourinary.
ऐसा क्यों होता है
Clarithromycin inhibits both CYP3A4 and P-glycoprotein, reducing colchicine metabolism and efflux and raising systemic levels with a narrow therapeutic index.
क्या करें
Avoid the combination, and choose a non-interacting antibiotic such as azithromycin or doxycycline where clinically appropriate. If a macrolide course is essential, withhold colchicine for the duration of treatment, and in patients with renal or hepatic impairment the combination should not be used at all.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Clarithromycin और Colchicine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Colchicine के अन्य इंटरैक्शन
- Cobicistat + Colchicine निषिद्ध
- Colchicine + Cyclosporine निषिद्ध
- Colchicine + Ensitrelvir निषिद्ध
- Colchicine + Levoketoconazole निषिद्ध
- Colchicine + Nirmatrelvir निषिद्ध
- Colchicine + Nirmatrelvir / ritonavir निषिद्ध
Clarithromycin के अन्य इंटरैक्शन
- Astemizole + Clarithromycin निषिद्ध
- Avanafil + Clarithromycin निषिद्ध
- Cisapride + Clarithromycin निषिद्ध
- Clarithromycin + Conivaptan निषिद्ध
- Clarithromycin + Dihydroergotamine निषिद्ध
- Clarithromycin + Dihydroergotamine intranasal निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Clarithromycin with Colchicine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin markedly increases colchicine exposure, and fatal colchicine toxicity has been reported with this combination. Presentations include severe gastrointestinal symptoms, myopathy, bone marrow suppression, multiorgan failure and death. Patients with renal or hepatic impairment and older adults are at greatest risk, but toxicity can occur even at standard colchicine doses.
How serious is the interaction between Clarithromycin and Colchicine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and choose a non-interacting antibiotic such as azithromycin or doxycycline where clinically appropriate. If a macrolide course is essential, withhold colchicine for the duration of treatment, and in patients with renal or hepatic impairment the combination should not be used at all.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Cobicistat, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
