दवाओं की अंतःक्रिया
Avapritinib + Chloramphenicol
गंभीरता: गंभीर
Avapritinib and Chloramphenicol: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Avapritinib is a CYP3A4 substrate and its exposure increases with CYP3A4 inhibitors, raising the risk of cognitive effects, intracranial bleeding and other toxicity. Chloramphenicol is a CYP3A4 inhibitor, though likely weaker than strong inhibitors.
इस इंटरैक्शन का सरल भाषा में अर्थ
Avapritinib and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
ऐसा क्यों होता है
Inhibition of CYP3A4-mediated metabolism of avapritinib.
क्या करें
Avoid the combination and choose another antibiotic. If necessary, monitor for cognitive changes, bleeding and other adverse effects, and consider avapritinib dose reduction.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Avapritinib और Chloramphenicol की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Chloramphenicol के अन्य इंटरैक्शन
Avapritinib के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Avapritinib with Chloramphenicol?
MediHelp rates the interaction as major. Avapritinib and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate and its exposure increases with CYP3A4 inhibitors, raising the risk of cognitive effects, intracranial bleeding and other toxicity. Chloramphenicol is a CYP3A4 inhibitor, though likely weaker than strong inhibitors.
How serious is the interaction between Avapritinib and Chloramphenicol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If necessary, monitor for cognitive changes, bleeding and other adverse effects, and consider avapritinib dose reduction.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Bcg vaccine live, Benzhydrocodone / acetaminophen. The full list is on the Chloramphenicol page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
