दवाओं की अंतःक्रिया
Chloramphenicol + Cobimetinib
गंभीरता: गंभीर
Chloramphenicol and Cobimetinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Chloramphenicol can inhibit CYP3A4 and may raise cobimetinib concentrations. Higher exposure may increase adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy, liver injury and cardiomyopathy.
इस इंटरैक्शन का सरल भाषा में अर्थ
Chloramphenicol and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
ऐसा क्यों होता है
Chloramphenicol inhibits CYP3A4-mediated metabolism of cobimetinib, a CYP3A substrate.
क्या करें
Avoid chloramphenicol in patients on cobimetinib and choose an antibiotic without CYP3A inhibition. If unavoidable, reduce the cobimetinib dose per labeling guidance for CYP3A inhibitors and monitor closely for toxicity.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Chloramphenicol और Cobimetinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Chloramphenicol के अन्य इंटरैक्शन
Cobimetinib के अन्य इंटरैक्शन
- Cobimetinib + Efavirenz निषिद्ध
- Cobimetinib + Posaconazole निषिद्ध
- Amobarbital + Cobimetinib गंभीर
- Apalutamide + Cobimetinib गंभीर
- Aprepitant + Cobimetinib गंभीर
- Bosentan + Cobimetinib गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Chloramphenicol with Cobimetinib?
MediHelp rates the interaction as major. Chloramphenicol and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4 and may raise cobimetinib concentrations. Higher exposure may increase adverse effects such as hemorrhage, rhabdomyolysis, serous retinopathy, liver injury and cardiomyopathy.
How serious is the interaction between Chloramphenicol and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chloramphenicol in patients on cobimetinib and choose an antibiotic without CYP3A inhibition. If unavoidable, reduce the cobimetinib dose per labeling guidance for CYP3A inhibitors and monitor closely for toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
