दवाओं की अंतःक्रिया
Ciprofloxacin + Cobimetinib
गंभीरता: गंभीर
Ciprofloxacin and Cobimetinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
इस इंटरैक्शन का सरल भाषा में अर्थ
Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
ऐसा क्यों होता है
Ciprofloxacin inhibits CYP3A4, reducing cobimetinib metabolism and raising its exposure.
क्या करें
Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Ciprofloxacin और Cobimetinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Ciprofloxacin के अन्य इंटरैक्शन
- Agomelatine + Ciprofloxacin निषिद्ध
- Ciprofloxacin + Fezolinetant निषिद्ध
- Ciprofloxacin + Thioridazine निषिद्ध
- Ciprofloxacin + Tizanidine निषिद्ध
- Ciprofloxacin + Vandetanib निषिद्ध
- Alosetron + Ciprofloxacin गंभीर
Cobimetinib के अन्य इंटरैक्शन
- Cobimetinib + Efavirenz निषिद्ध
- Cobimetinib + Posaconazole निषिद्ध
- Amobarbital + Cobimetinib गंभीर
- Apalutamide + Cobimetinib गंभीर
- Aprepitant + Cobimetinib गंभीर
- Bosentan + Cobimetinib गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Ciprofloxacin with Cobimetinib?
MediHelp rates the interaction as major. Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
How serious is the interaction between Ciprofloxacin and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
