दवाओं की अंतःक्रिया
Ciprofloxacin + Tizanidine
गंभीरता: निषिद्ध
Ciprofloxacin and Tizanidine: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.
इस इंटरैक्शन का सरल भाषा में अर्थ
Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ciprofloxacin belongs to Anti Bacterial; Tizanidine belongs to Musculoskeletal.
ऐसा क्यों होता है
Ciprofloxacin is a potent CYP1A2 inhibitor and blocks the main metabolic pathway of tizanidine, greatly increasing its systemic exposure.
क्या करें
Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Ciprofloxacin और Tizanidine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Tizanidine के अन्य इंटरैक्शन
Ciprofloxacin के अन्य इंटरैक्शन
- Agomelatine + Ciprofloxacin निषिद्ध
- Ciprofloxacin + Fezolinetant निषिद्ध
- Ciprofloxacin + Thioridazine निषिद्ध
- Ciprofloxacin + Vandetanib निषिद्ध
- Alosetron + Ciprofloxacin गंभीर
- Aluminum hydroxide + Ciprofloxacin गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Ciprofloxacin with Tizanidine?
MediHelp rates the interaction as contraindicated. Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.
How serious is the interaction between Ciprofloxacin and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Fluvoxamine, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
