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दवाओं की अंतःक्रिया

Clarithromycin + Tisotumab vedotin

गंभीरता: मध्यम

Clarithromycin and Tisotumab vedotin: moderate interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.

इस इंटरैक्शन का सरल भाषा में अर्थ

Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clarithromycin belongs to Anti Bacterial; Tisotumab vedotin belongs to Oncology.

साक्ष्य स्तर: Moderate

ऐसा क्यों होता है

Clarithromycin inhibits CYP3A4 metabolism of MMAE.

क्या करें

Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.

फार्मासिस्ट से क्या पूछें

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Clarithromycin और Tisotumab vedotin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Clarithromycin with Tisotumab vedotin?

MediHelp rates the interaction as moderate. Clarithromycin and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The cytotoxic payload MMAE from tisotumab vedotin is a CYP3A4 substrate. A strong inhibitor like clarithromycin may raise MMAE exposure and increase toxicity, including neuropathy, neutropenia and ocular effects.

How serious is the interaction between Clarithromycin and Tisotumab vedotin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-CYP3A4-inhibiting antibiotic. If combined, monitor for adverse reactions of tisotumab vedotin.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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