दवाओं की अंतःक्रिया
Dexamethasone-neomycin-polymyxin + Lapatinib
गंभीरता: गंभीर
Dexamethasone-neomycin-polymyxin and Lapatinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
इस इंटरैक्शन का सरल भाषा में अर्थ
Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lapatinib belongs to Oncology.
ऐसा क्यों होता है
Dexamethasone induces CYP3A4 and increases lapatinib clearance, while lapatinib weakly inhibits CYP3A4 and P-glycoprotein.
क्या करें
Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Dexamethasone-neomycin-polymyxin और Lapatinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Dexamethasone-neomycin-polymyxin के अन्य इंटरैक्शन
- Dexamethasone-neomycin-polymyxin + Ketorolac गंभीर
- Dexamethasone-neomycin-polymyxin + Levofloxacin गंभीर
- Dexamethasone-neomycin-polymyxin + Mifepristone गंभीर
- Dexamethasone-neomycin-polymyxin + Moxifloxacin गंभीर
- Aldesleukin + Dexamethasone-neomycin-polymyxin मध्यम
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin मध्यम
Lapatinib के अन्य इंटरैक्शन
- Dofetilide + Lapatinib निषिद्ध
- Ibutilide + Lapatinib निषिद्ध
- Lapatinib + Pimozide निषिद्ध
- Lapatinib + Saquinavir निषिद्ध
- Lapatinib + Thioridazine निषिद्ध
- Adagrasib + Lapatinib गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Dexamethasone-neomycin-polymyxin with Lapatinib?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
