दवाओं की अंतःक्रिया
Dexmethylphenidate + Safinamide
गंभीरता: निषिद्ध
Dexmethylphenidate and Safinamide: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
इस इंटरैक्शन का सरल भाषा में अर्थ
Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
ऐसा क्यों होता है
MAO inhibition reduces catecholamine breakdown while the stimulant increases catecholamine release and blocks reuptake, producing additive sympathomimetic effects.
क्या करें
Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Dexmethylphenidate और Safinamide की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Safinamide के अन्य इंटरैक्शन
- Amitriptyline + Safinamide निषिद्ध
- Amoxapine + Safinamide निषिद्ध
- Amphetamine polistirex + Safinamide निषिद्ध
- Clomipramine + Safinamide निषिद्ध
- Cyclobenzaprine + Safinamide निषिद्ध
- Desipramine + Safinamide निषिद्ध
Dexmethylphenidate के अन्य इंटरैक्शन
- Dexmethylphenidate + Isocarboxazid निषिद्ध
- Dexmethylphenidate + Linezolid निषिद्ध
- Dexmethylphenidate + Phenelzine निषिद्ध
- Dexmethylphenidate + Procarbazine निषिद्ध
- Dexmethylphenidate + Rasagiline निषिद्ध
- Dexmethylphenidate + Selegiline निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Dexmethylphenidate with Safinamide?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is a MAO-B inhibitor and dexmethylphenidate is a CNS stimulant that raises synaptic dopamine and norepinephrine. Combining them can precipitate a hypertensive crisis and hyperadrenergic or serotonergic toxicity. The labeling of both classes advises against concurrent use.
How serious is the interaction between Dexmethylphenidate and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow a washout of at least 14 days after stopping safinamide before starting dexmethylphenidate. Choose a non-interacting alternative for ADHD.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
