दवाओं की अंतःक्रिया
Dihydroergotamine + Miconazole
गंभीरता: गंभीर
Dihydroergotamine and Miconazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Dihydroergotamine is cleared mainly by CYP3A4, and strong inhibition of this enzyme can raise ergot levels sharply, causing ergotism with severe peripheral and cerebral vasospasm and ischemia. Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, systemic exposure can occur and ergot toxicity is potentially catastrophic.
इस इंटरैक्शन का सरल भाषा में अर्थ
Dihydroergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dihydroergotamine belongs to Central Nervous System; Miconazole belongs to Anti Fungals.
ऐसा क्यों होता है
Miconazole inhibits CYP3A4-mediated metabolism of dihydroergotamine, increasing its systemic concentrations.
क्या करें
Avoid the combination where possible, and prefer a topical antifungal with minimal absorption or an alternative to the ergot. If used together, counsel the patient to report numbness, cold or painful extremities, or chest pain immediately.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Dihydroergotamine और Miconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Miconazole के अन्य इंटरैक्शन
Dihydroergotamine के अन्य इंटरैक्शन
- Almotriptan + Dihydroergotamine निषिद्ध
- Clarithromycin + Dihydroergotamine निषिद्ध
- Dihydroergotamine + Dopamine निषिद्ध
- Dihydroergotamine + Dronedarone निषिद्ध
- Dihydroergotamine + Efavirenz निषिद्ध
- Dihydroergotamine + Eletriptan निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Dihydroergotamine with Miconazole?
MediHelp rates the interaction as major. Dihydroergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dihydroergotamine is cleared mainly by CYP3A4, and strong inhibition of this enzyme can raise ergot levels sharply, causing ergotism with severe peripheral and cerebral vasospasm and ischemia. Miconazole is a CYP3A4 inhibitor and, although vaginal absorption is low, systemic exposure can occur and ergot toxicity is potentially catastrophic.
How serious is the interaction between Dihydroergotamine and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and prefer a topical antifungal with minimal absorption or an alternative to the ergot. If used together, counsel the patient to report numbness, cold or painful extremities, or chest pain immediately.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Ergotamine. The full list is on the Miconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
