दवाओं की अंतःक्रिया
Methadone + Miconazole
गंभीरता: गंभीर
Methadone and Miconazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Methadone is metabolized by CYP3A4, CYP2B6 and CYP2D6, and azole inhibitors can raise its levels. Higher methadone exposure risks excess sedation, respiratory depression and QT prolongation. Miconazole itself can also prolong the QT interval.
इस इंटरैक्शन का सरल भाषा में अर्थ
Methadone and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methadone belongs to Musculoskeletal; Miconazole belongs to Anti Fungals.
ऐसा क्यों होता है
Miconazole inhibits CYP3A4 (and CYP2B6/2D6), reducing methadone clearance, with possible additive QT effects.
क्या करें
Monitor for sedation, respiratory depression and QT prolongation, with an ECG if there are other risk factors. Reduce the methadone dose if signs of excess appear, and prefer a topical non-azole option if possible.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Methadone और Miconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Miconazole के अन्य इंटरैक्शन
Methadone के अन्य इंटरैक्शन
- Alvimopan + Methadone निषिद्ध
- Calcium / magnesium / potassium / sodium oxybates + Methadone निषिद्ध
- Droperidol + Methadone निषिद्ध
- Ibutilide + Methadone निषिद्ध
- Isocarboxazid + Methadone निषिद्ध
- Lefamulin + Methadone निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Methadone with Miconazole?
MediHelp rates the interaction as major. Methadone and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methadone is metabolized by CYP3A4, CYP2B6 and CYP2D6, and azole inhibitors can raise its levels. Higher methadone exposure risks excess sedation, respiratory depression and QT prolongation. Miconazole itself can also prolong the QT interval.
How serious is the interaction between Methadone and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and QT prolongation, with an ECG if there are other risk factors. Reduce the methadone dose if signs of excess appear, and prefer a topical non-azole option if possible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
