दवाओं की अंतःक्रिया
Dihydroergotamine intranasal + Miconazole
गंभीरता: गंभीर
Dihydroergotamine intranasal and Miconazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Intranasal dihydroergotamine is still metabolized by CYP3A4, so inhibitors of this enzyme can increase systemic ergot exposure and the risk of vasospastic ischemia. Miconazole can inhibit CYP3A4 after systemic absorption, and ergotism can be severe.
इस इंटरैक्शन का सरल भाषा में अर्थ
Dihydroergotamine intranasal and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Miconazole inhibits CYP3A4-mediated metabolism of dihydroergotamine, increasing its systemic concentrations.
क्या करें
Avoid the combination where possible and select a non-interacting antifungal or migraine therapy. If unavoidable, monitor for signs of peripheral ischemia such as cold, numb or painful limbs.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Dihydroergotamine intranasal और Miconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Miconazole के अन्य इंटरैक्शन
- Cabazitaxel + Miconazole गंभीर
- Dihydroergotamine + Miconazole गंभीर
- Ergotamine + Miconazole गंभीर
- Glyburide + Miconazole गंभीर
- Lovastatin + Miconazole गंभीर
- Methadone + Miconazole गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Dihydroergotamine intranasal with Miconazole?
MediHelp rates the interaction as major. Dihydroergotamine intranasal and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intranasal dihydroergotamine is still metabolized by CYP3A4, so inhibitors of this enzyme can increase systemic ergot exposure and the risk of vasospastic ischemia. Miconazole can inhibit CYP3A4 after systemic absorption, and ergotism can be severe.
How serious is the interaction between Dihydroergotamine intranasal and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and select a non-interacting antifungal or migraine therapy. If unavoidable, monitor for signs of peripheral ischemia such as cold, numb or painful limbs.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine, Ergotamine. The full list is on the Miconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
