दवाओं की अंतःक्रिया
Domperidone + Erythromycin
गंभीरता: निषिद्ध
Domperidone and Erythromycin: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
इस इंटरैक्शन का सरल भाषा में अर्थ
Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Domperidone belongs to Gastrointestinal Tract; Erythromycin belongs to Anti Bacterial.
ऐसा क्यों होता है
Erythromycin inhibits CYP3A4, the main metabolic pathway of domperidone, and both drugs block the hERG potassium channel, giving additive QT prolongation.
क्या करें
Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Domperidone और Erythromycin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
- Domperidone SmPC - Contraindications and Interactions — EMA SmPC
- Erythromycin Prescribing Information - Drug Interactions — FDA Label
Domperidone के अन्य इंटरैक्शन
Erythromycin के अन्य इंटरैक्शन
- Conivaptan + Erythromycin निषिद्ध
- Dihydroergotamine intranasal + Erythromycin निषिद्ध
- Dihydroergotamine + Erythromycin निषिद्ध
- Dronedarone + Erythromycin निषिद्ध
- Droperidol + Erythromycin निषिद्ध
- Ergotamine + Erythromycin निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Domperidone with Erythromycin?
MediHelp rates the interaction as contraindicated. Domperidone and Erythromycin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Erythromycin markedly raises domperidone exposure and both drugs prolong the QT interval, increasing the risk of torsades de pointes and sudden cardiac death. Domperidone labeling in Europe contraindicates co-administration with QT-prolonging drugs and potent CYP3A4 inhibitors. Risk is greater in older patients, those with cardiac disease, electrolyte disturbances or higher domperidone doses.
How serious is the interaction between Domperidone and Erythromycin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a non-QT-prolonging antiemetic or prokinetic, or a different antibiotic such as one without CYP3A4 inhibition or QT effects. If erythromycin is essential, withhold domperidone for the course.
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Dexlansoprazole, Lansoprazole. The full list is on the Domperidone page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
