दवाओं की अंतःक्रिया
Domperidone + Lansoprazole
गंभीरता: मध्यम
Domperidone and Lansoprazole: moderate interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Long-term lansoprazole use can cause hypomagnesemia, and low magnesium (often with low potassium) increases susceptibility to QT prolongation and torsades de pointes with domperidone. The risk is mainly seen with prolonged PPI therapy and is greatest in older patients, those on diuretics or digoxin, and those with structural heart disease or other QT-prolonging drugs. The interaction is indirect and uncommon but potentially serious.
इस इंटरैक्शन का सरल भाषा में अर्थ
Domperidone and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Domperidone belongs to Gastrointestinal Tract; Lansoprazole belongs to Gastrointestinal Tract.
ऐसा क्यों होता है
Pharmacodynamic and indirect: PPI-induced hypomagnesemia (reduced intestinal magnesium absorption) lowers the repolarisation reserve, potentiating the QT-prolonging hERG-blocking effect of domperidone.
क्या करें
Check magnesium and potassium before starting domperidone in patients on long-term lansoprazole, and correct deficits. Use the lowest effective domperidone dose for the shortest time (labelling advises a maximum of 30 mg/day and about one week for nausea/vomiting).
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Domperidone और Lansoprazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
- Prevacid (lansoprazole) Prescribing Information - Warnings: Hypomagnesemia — FDA Label
- Domperidone - Summary of Product Characteristics: Cardiac effects and QT prolongation — EMA SmPC
- PRAC recommendation: Domperidone-containing medicines - restricted use (2014) — EMA
Domperidone के अन्य इंटरैक्शन
Lansoprazole के अन्य इंटरैक्शन
- Lansoprazole + Mavacamten निषिद्ध
- Lansoprazole + Rilpivirine निषिद्ध
- Acalabrutinib + Lansoprazole गंभीर
- Atazanavir + Lansoprazole गंभीर
- Dacomitinib + Lansoprazole गंभीर
- Dasatinib + Lansoprazole गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Domperidone with Lansoprazole?
MediHelp rates the interaction as moderate. Domperidone and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term lansoprazole use can cause hypomagnesemia, and low magnesium (often with low potassium) increases susceptibility to QT prolongation and torsades de pointes with domperidone. The risk is mainly seen with prolonged PPI therapy and is greatest in older patients, those on diuretics or digoxin, and those with structural heart disease or other QT-prolonging drugs. The interaction is indirect and uncommon but potentially serious.
How serious is the interaction between Domperidone and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check magnesium and potassium before starting domperidone in patients on long-term lansoprazole, and correct deficits. Use the lowest effective domperidone dose for the shortest time (labelling advises a maximum of 30 mg/day and about one week for nausea/vomiting).
What other medicines interact with Domperidone?
MediHelp also lists interactions of Domperidone with, for example, Azithromycin, Erythromycin, Dexlansoprazole. The full list is on the Domperidone page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
