दवाओं की अंतःक्रिया
Fosphenytoin + Ledipasvir-sofosbuvir
गंभीरता: निषिद्ध
Fosphenytoin and Ledipasvir-sofosbuvir: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Fosphenytoin is converted to phenytoin, a potent inducer of intestinal P-glycoprotein and other enzymes, which can substantially lower sofosbuvir and ledipasvir exposure. This may lead to loss of antiviral efficacy and hepatitis C treatment failure or resistance.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fosphenytoin and Ledipasvir-sofosbuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fosphenytoin belongs to Central Nervous System; Ledipasvir-sofosbuvir belongs to Anti Virals.
ऐसा क्यों होता है
Phenytoin induces intestinal P-glycoprotein, reducing absorption and plasma concentrations of sofosbuvir and ledipasvir.
क्या करें
Do not co-administer. Switch to a non-inducing antiepileptic such as levetiracetam before starting the hepatitis C regimen, under neurology guidance.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fosphenytoin और Ledipasvir-sofosbuvir की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Ledipasvir-sofosbuvir के अन्य इंटरैक्शन
Fosphenytoin के अन्य इंटरैक्शन
- Dronedarone + Fosphenytoin निषिद्ध
- Fosphenytoin + Lorlatinib निषिद्ध
- Fosphenytoin + Lurasidone निषिद्ध
- Fosphenytoin + Ranolazine निषिद्ध
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir निषिद्ध
- Abiraterone + Fosphenytoin गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Fosphenytoin with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as contraindicated. Fosphenytoin and Ledipasvir-sofosbuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosphenytoin is converted to phenytoin, a potent inducer of intestinal P-glycoprotein and other enzymes, which can substantially lower sofosbuvir and ledipasvir exposure. This may lead to loss of antiviral efficacy and hepatitis C treatment failure or resistance.
How serious is the interaction between Fosphenytoin and Ledipasvir-sofosbuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Switch to a non-inducing antiepileptic such as levetiracetam before starting the hepatitis C regimen, under neurology guidance.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Phenobarbital, Phenytoin, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
