दवाओं की अंतःक्रिया
Ledipasvir-sofosbuvir + Phenytoin
गंभीरता: निषिद्ध
Ledipasvir-sofosbuvir and Phenytoin: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
इस इंटरैक्शन का सरल भाषा में अर्थ
Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ledipasvir-sofosbuvir belongs to Anti Virals; Phenytoin belongs to Central Nervous System.
ऐसा क्यों होता है
Phenytoin induces P-glycoprotein and metabolic enzymes, reducing absorption and exposure of sofosbuvir and ledipasvir.
क्या करें
Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Ledipasvir-sofosbuvir और Phenytoin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Ledipasvir-sofosbuvir के अन्य इंटरैक्शन
Phenytoin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Ledipasvir-sofosbuvir with Phenytoin?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is an inducer of P-gp and CYP enzymes and is expected to substantially reduce ledipasvir and sofosbuvir exposure. This can cause failure of hepatitis C therapy. Labeling advises against use together.
How serious is the interaction between Ledipasvir-sofosbuvir and Phenytoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; replace phenytoin with a non-inducing antiepileptic before and during HCV treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
