दवाओं की अंतःक्रिया
Ledipasvir-sofosbuvir + St john's wort
गंभीरता: निषिद्ध
Ledipasvir-sofosbuvir and St john's wort: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
इस इंटरैक्शन का सरल भाषा में अर्थ
Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Induction of intestinal P-glycoprotein (and other inducible pathways) by St John's wort reduces absorption and plasma exposure of ledipasvir and sofosbuvir.
क्या करें
Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Ledipasvir-sofosbuvir और St john's wort की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Ledipasvir-sofosbuvir के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Ledipasvir-sofosbuvir with St john's wort?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
How serious is the interaction between Ledipasvir-sofosbuvir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
