दवाओं की अंतःक्रिया
Pipemidic acid + Tizanidine
गंभीरता: निषिद्ध
Pipemidic acid and Tizanidine: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Pipemidic acid is a CYP1A2 inhibitor and can markedly raise tizanidine exposure. This may cause profound hypotension, bradycardia and sedation. Related fluoroquinolone CYP1A2 inhibitors are contraindicated with tizanidine.
इस इंटरैक्शन का सरल भाषा में अर्थ
Pipemidic acid and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Inhibition of CYP1A2-mediated tizanidine metabolism increases plasma concentrations.
क्या करें
Avoid the combination and choose an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use an alternative muscle relaxant.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Pipemidic acid और Tizanidine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Tizanidine के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Pipemidic acid with Tizanidine?
MediHelp rates the interaction as contraindicated. Pipemidic acid and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pipemidic acid is a CYP1A2 inhibitor and can markedly raise tizanidine exposure. This may cause profound hypotension, bradycardia and sedation. Related fluoroquinolone CYP1A2 inhibitors are contraindicated with tizanidine.
How serious is the interaction between Pipemidic acid and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use an alternative muscle relaxant.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
