दवाओं की अंतःक्रिया
Pefloxacin + Tizanidine
गंभीरता: निषिद्ध
Pefloxacin and Tizanidine: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Pefloxacin inhibits CYP1A2, the main enzyme clearing tizanidine, so tizanidine levels can rise markedly. This can cause severe hypotension, bradycardia and profound sedation, as seen with the related drug ciprofloxacin.
इस इंटरैक्शन का सरल भाषा में अर्थ
Pefloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pefloxacin belongs to Anti Bacterial; Tizanidine belongs to Musculoskeletal.
ऐसा क्यों होता है
Inhibition of CYP1A2 by pefloxacin reduces tizanidine clearance.
क्या करें
Avoid the combination and use an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use a much lower tizanidine dose and monitor blood pressure and heart rate closely.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Pefloxacin और Tizanidine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Tizanidine के अन्य इंटरैक्शन
Pefloxacin के अन्य इंटरैक्शन
- Clozapine + Pefloxacin गंभीर
- Duloxetine + Pefloxacin गंभीर
- Pefloxacin + Theophylline गंभीर
- Asenapine + Pefloxacin मध्यम
- Caffeine + Pefloxacin मध्यम
- Cimetidine + Pefloxacin मध्यम
अक्सर पूछे जाने वाले प्रश्न
Can I take Pefloxacin with Tizanidine?
MediHelp rates the interaction as contraindicated. Pefloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pefloxacin inhibits CYP1A2, the main enzyme clearing tizanidine, so tizanidine levels can rise markedly. This can cause severe hypotension, bradycardia and profound sedation, as seen with the related drug ciprofloxacin.
How serious is the interaction between Pefloxacin and Tizanidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antibiotic that does not inhibit CYP1A2. If it cannot be avoided, use a much lower tizanidine dose and monitor blood pressure and heart rate closely.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pipemidic acid. The full list is on the Tizanidine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
