Riferimento farmaci
Linaclotide
Linaclotide is a medicine in the class gastrointestinal tract. It is used for constipation.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: constipation
Ultimo aggiornamento Fonti: US FDA label, EMA SmPC
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Codice ATC
- A06AX04
- Forme farmaceutiche comuni
- capsula
- Interazioni note
- 2 (Moderata: 2)
- Nomi commerciali
- 3
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Linaclotide and its active metabolite are guanylate cyclase-C agonists acting locally on the intestinal epithelium. Raised cGMP stimulates chloride and bicarbonate secretion via CFTR, increasing intestinal fluid and accelerating transit.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
IBS-C: 290 mcg orally once daily
Gravidanza e allattamento
- Gravidanza
- Unknown Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk.
- Allattamento
- Safe Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
Effetti indesiderati segnalati
- Diarrhea
- Abdominal pain
- Flatulence
- Abdominal distension
- Viral gastroenteritis
- Headache
Avvertenze in evidenza
- Risk of serious dehydration in pediatric patients less than 2 years of age. Contraindicated in this age group; in neonatal mice a single clinically relevant adult oral dose caused deaths due to dehydration.
Controindicazioni
- Patients less than 2 years of age due to risk of serious dehydration.
- Known or suspected mechanical gastrointestinal obstruction.
Chi deve prestare attenzione
- Severe diarrhea may occur; post-marketing cases with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia, hyponatremia) required hospitalization or IV fluids.
- Insufficient data on GC-C intestinal expression in children under 2 years to assess risk of diarrhea and its serious consequences.
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Interazioni principali (2)
- Linaclotide + Lubiprostone Moderate
- Linaclotide + Mosapride Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Letture rapide correlate
Domande frequenti
What is Linaclotide used for?
Linaclotide is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Linaclotide?
Diarrhea, Abdominal pain, Flatulence, Abdominal distension, Viral gastroenteritis, Headache. Serious warning: Risk of serious dehydration in pediatric patients less than 2 years of age.
Can Linaclotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Negligibly absorbed systemically; maternal use not expected to result in fetal exposure. Available human data insufficient to inform drug-associated risk. Breastfeeding: Safe. Linaclotide and its active metabolite were not detected in milk; exposure of breastfed infants not expected. Consider benefits of breastfeeding with maternal need.
What does Linaclotide interact with?
MediHelp lists 2 known interactions for Linaclotide. Moderate: 2. The most serious include Lubiprostone, Mosapride.
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