Riferimento farmaci
Lopinavir
Lopinavir is a medicine in the class anti virals. It is used for hiv.
- Classe del farmaco: Anti Virals
- Indicato per: hiv
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Anti Virals
- Interazioni note
- 274 (Controindicata: 16 · Maggiore: 115 · Moderata: 128 · Minore: 15)
Per cosa si usa
Come agisce
HIV-1 protease inhibitor; antiviral activity of the lopinavir/ritonavir combination is due to lopinavir, while ritonavir inhibits CYP3A metabolism of lopinavir and raises its plasma levels.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
HIV-1 infection: tablets 400/100 mg (two 200/50 mg tablets) twice daily, or oral solution 400/100 mg (5 mL) twice daily, with other antiretrovirals
Gravidanza e allattamento
- Gravidanza
- Safe Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment.
- Allattamento
- Safe Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
Effetti indesiderati segnalati
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Asthenia
Controindicazioni
- Hypersensitivity to any ingredient, including ritonavir (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme).
- Co-administration with drugs highly dependent on CYP3A for clearance where elevated levels cause serious or life-threatening reactions.
- Co-administration with potent CYP3A inducers (loss of virologic response); Table 3 lists alfuzosin, rifampin, ergot derivatives, cisapride, St. John's Wort, lovastatin, simvastatin, sildenafil (Revatio), pimozide, triazolam, oral midazolam.
Chi deve prestare attenzione
- CYP3A inhibition can raise levels of concomitant drugs, causing severe or fatal events; review all medications.
- Pancreatitis, including fatalities; suspend therapy as clinically appropriate if suspected.
- Hepatotoxicity: monitor liver function, especially with underlying hepatitis B or C or cirrhosis.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (274)
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
- Flibanserin + Lopinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Ivabradine + Lopinavir Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Lopinavir used for?
Lopinavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Lopinavir?
Diarrhea, Nausea, Vomiting, Abdominal pain, Headache, Asthenia.
Can Lopinavir be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment. Breastfeeding: Safe. Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Lopinavir interact with?
MediHelp lists 274 known interactions for Lopinavir. Contraindicated: 16 · Major: 115 · Moderate: 128 · Minor: 15. The most serious include Alfuzosin, Avanafil, Cisapride.
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