Interazioni tra farmaci
Eletriptan + Lopinavir
Gravità: Controindicata
Eletriptan and Lopinavir: contraindicated interaction.
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Sintesi
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
Cosa significa questa interazione in parole semplici
Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Perché avviene
CYP3A4 inhibition (mainly by the ritonavir component) reducing eletriptan clearance.
Cosa fare
Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Eletriptan
- Almotriptan + Eletriptan Controindicata
- Atazanavir + Eletriptan Controindicata
- Ceritinib + Eletriptan Controindicata
- Clarithromycin + Eletriptan Controindicata
- Cobicistat + Eletriptan Controindicata
- Conivaptan + Eletriptan Controindicata
Altre interazioni di Lopinavir
- Alfuzosin + Lopinavir Controindicata
- Avanafil + Lopinavir Controindicata
- Cisapride + Lopinavir Controindicata
- Dronedarone + Lopinavir Controindicata
- Eplerenone + Lopinavir Controindicata
- Ergotamine + Lopinavir Controindicata
Domande frequenti
Can I take Eletriptan with Lopinavir?
MediHelp rates the interaction as contraindicated. Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
How serious is the interaction between Eletriptan and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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