Riferimento farmaci
Mafenide
Mafenide is a medicine in the class dermatology. It is used for burns.
- Classe del farmaco: Dermatology
- Indicato per: burns
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Dermatology
- Forme farmaceutiche comuni
- crema
- Dosaggi comuni
- 85 mg/g
- Interazioni note
- 1 (Maggiore: 1)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Applied topically, it markedly reduces the bacterial population in the avascular tissues of second- and third-degree burns and exerts bacteriostatic action against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Second- and third-degree burns (adjunctive): apply cream topically with sterile gloved hand once or twice daily to a thickness of approximately 1/16 inch; keep burned areas covered with cream at all times; continue until healing is progressing well or site is ready for grafting.
Gravidanza e allattamento
- Gravidanza
- Unknown Burn cream/solution; absorbed through large burns. No animal reproduction studies; fetal risk unknown. US label: not recommended in women who could become pregnant unless the burn covers more than 20% of the body or the benefit outweighs the possible fetal risk.
- Allattamento
- Unknown Not known if it passes into milk; no LactMed or e-lactancia record. US label: decide whether to stop breastfeeding or the drug. Large burns give real absorption (it can cause metabolic acidosis), so avoid if possible; never apply to the breast.
Effetti indesiderati segnalati
- Pain or burning sensation on application
- Rash
- Itching
- Facial edema
- Eosinophilia
- Tachypnea or hyperventilation
Controindicazioni
- Hypersensitivity to the drug; cross-sensitivity to other sulfonamides is not known.
Chi deve prestare attenzione
- Fatal hemolytic anemia with disseminated intravascular coagulation, presumably related to G6PD deficiency, has been reported.
- Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylaxis and asthmatic episodes in susceptible people.
- Mafenide and its metabolite inhibit carbonic anhydrase, which may cause metabolic acidosis; monitor acid-base balance closely, especially in extensive second-degree burns and pulmonary or renal dysfunction.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (1)
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- Renal and hepatic dose adjustments
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- Pharmacokinetics
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Altri farmaci della stessa classe
Domande frequenti
What is Mafenide used for?
Mafenide is a medicine in the class dermatology. It is used for Burns.
What side effects have been reported with Mafenide?
Pain or burning sensation on application, Rash, Itching, Facial edema, Eosinophilia, Tachypnea or hyperventilation.
Can Mafenide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Burn cream/solution; absorbed through large burns. No animal reproduction studies; fetal risk unknown. US label: not recommended in women who could become pregnant unless the burn covers more than 20% of the body or the benefit outweighs the possible fetal risk. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed or e-lactancia record. US label: decide whether to stop breastfeeding or the drug. Large burns give real absorption (it can cause metabolic acidosis), so avoid if possible; never apply to the breast.
What does Mafenide interact with?
MediHelp lists 1 known interactions for Mafenide. Major: 1. The most serious include Dichlorphenamide.
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