Riferimento farmaci
Orphenadrin
Orphenadrin is a medicine in the class musculoskeletal. It is used for muscle spasm.
- Classe del farmaco: Musculoskeletal
- Indicato per: muscle spasm
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In breve
- Classe del farmaco
- Musculoskeletal
- Forme farmaceutiche comuni
- compressa, iniezione
- Dosaggi comuni
- 30 mg/ml, 100 mg
- Interazioni note
- 225 (Maggiore: 42 · Moderata: 159 · Minore: 24)
- Nomi commerciali
- 2
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
May work through central atropine-like effect; anticholinergic activity in brain stem; has euphorigenic and analgesic properties
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Muscle Spasm & Pain: 100 mg PO q12hr OR 60 mg IV/IM q12hr (switch to PO as soon as possible)
Gravidanza e allattamento
- Gravidanza
- Unknown Long used without apparent harm, but safety is not established; animal studies found no hazard (UK label). Labels: use only if clearly needed, with caution. Prefer non-drug measures or paracetamol for muscle pain where possible.
- Allattamento
- Unknown No published data; the UK label says milk amounts are unlikely to be significant at usual doses; use with caution. LactMed: its anticholinergic action might reduce milk supply; an alternative may be preferred. If used, watch milk supply and infant drowsiness.
Effetti indesiderati segnalati
- Drowsiness
- Dry mouth
- Lightheadedness
- Tachycardia
- Urinary retention
- Weakness
Controindicazioni
- Hypersensitivity
- Narrow-angle glaucoma
- Pyloric/duodenal obstruction, BPH, stenosing peptic ulcers, cardiospasm (mega-esophagus), myasthenia gravis, obstructive uropathy, paralytic ileus, ulcerative colitis, toxic megacolon, achalasia
Chi deve prestare attenzione
- Contraindicated in Pyloric/duodenal obstruction, BPH, and stenosing peptic ulcers.
- Safety of long-term therapy not established; if orphenadrine is prescribed for prolonged use, periodic monitoring of blood, urine and liver function is recommended
- Some patients may experience transient episodes of light-headedness, dizziness or syncope.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (225)
- Alfentanil + Orphenadrin Major
- Amobarbital + Orphenadrin Major
- Benzhydrocodone / acetaminophen + Orphenadrin Major
- Brexanolone + Orphenadrin Major
- Buprenorphine + Orphenadrin Major
- Buprenorphine buccal + Orphenadrin Major
- Buprenorphine long-acting + Orphenadrin Major
- Buprenorphine subdermal implant + Orphenadrin Major
- Buprenorphine transdermal + Orphenadrin Major
- Calcium / magnesium / potassium / sodium oxybates + Orphenadrin Major
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Orphenadrin used for?
Orphenadrin is a medicine in the class musculoskeletal. It is used for Muscle spasm, Pain management.
What side effects have been reported with Orphenadrin?
Drowsiness, Dry mouth, Lightheadedness, Tachycardia, Urinary retention, Weakness.
Can Orphenadrin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Long used without apparent harm, but safety is not established; animal studies found no hazard (UK label). Labels: use only if clearly needed, with caution. Prefer non-drug measures or paracetamol for muscle pain where possible. Breastfeeding: Unknown. No published data; the UK label says milk amounts are unlikely to be significant at usual doses; use with caution. LactMed: its anticholinergic action might reduce milk supply; an alternative may be preferred. If used, watch milk supply and infant drowsiness.
What does Orphenadrin interact with?
MediHelp lists 225 known interactions for Orphenadrin. Major: 42 · Moderate: 159 · Minor: 24. The most serious include Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen.
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