Riferimento farmaci
Pasireotide
Pasireotide is a medicine in the class endocrine. It is used for cushing syndrome.
- Classe del farmaco: Endocrine
- Indicato per: cushing syndrome
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Endocrine
- Codice ATC
- H01CB05
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 20 mg
- Interazioni note
- 125 (Controindicata: 2 · Maggiore: 44 · Moderata: 78 · Minore: 1)
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Injectable cyclohexapeptide somatostatin analogue that binds and activates somatostatin receptors (notably SSTR5, over-expressed in corticotroph tumors), inhibiting ACTH secretion and thereby decreasing cortisol secretion.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Cushing's disease: initial 0.6 mg or 0.9 mg subcutaneously twice a day; range 0.3 mg to 0.9 mg twice a day; titrate to response and tolerability
Gravidanza e allattamento
- Gravidanza
- Unknown Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception.
- Allattamento
- Unknown No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
Effetti indesiderati segnalati
- Diarrhea
- Nausea
- Hyperglycemia
- Cholelithiasis
- Headache
- Abdominal pain
Controindicazioni
- None.
Chi deve prestare attenzione
- Hypocortisolism may occur; monitor, and consider dose reduction or interruption and temporary glucocorticoid replacement.
- Hyperglycemia and diabetes: monitor glycemia weekly for first two to three months and after dose increases; optimize antidiabetic therapy before starting.
- Bradycardia and QT prolongation: use caution in at-risk patients; baseline ECG recommended; correct hypokalemia and hypomagnesemia.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (125)
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
- Asenapine + Pasireotide Major
- Azithromycin + Pasireotide Major
- Citalopram + Pasireotide Major
- Clarithromycin + Pasireotide Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Pasireotide used for?
Pasireotide is a medicine in the class endocrine. It is used for Cushing syndrome.
What side effects have been reported with Pasireotide?
Diarrhea, Nausea, Hyperglycemia, Cholelithiasis, Headache, Abdominal pain.
Can Pasireotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception. Breastfeeding: Unknown. No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
What does Pasireotide interact with?
MediHelp lists 125 known interactions for Pasireotide. Contraindicated: 2 · Major: 44 · Moderate: 78 · Minor: 1. The most serious include Dronedarone, Pimozide, Amiodarone.
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