Riferimento farmaci
Telotristat etiprate
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for diarrhea.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: diarrhea
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Interazioni note
- 12 (Moderata: 10 · Minore: 2)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Telotristat ethyl and its active metabolite telotristat inhibit L-tryptophan hydroxylases (TPH1 and TPH2), the rate-limiting steps in serotonin biosynthesis. By inhibiting peripheral TPH1 it reduces serotonin production and eases carcinoid syndrome symptoms.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Carcinoid syndrome diarrhoea (with somatostatin analogue therapy, adults inadequately controlled by SSA): 250 mg orally three times daily; higher doses not recommended; reassess benefit if no response within 12 weeks
Gravidanza e allattamento
- Gravidanza
- Unknown No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception.
- Allattamento
- Unknown No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
Effetti indesiderati segnalati
- Abdominal pain
- Gamma-glutamyl transferase increased
- Fatigue
- Abdominal distension
- Flatulence
- Constipation
Controindicazioni
- Hypersensitivity to the active substance or to any excipients.
Chi deve prestare attenzione
- Hepatic enzyme elevations: monitor liver enzymes before and during therapy as clinically indicated; discontinue if liver injury is suspected and do not resume unless another cause is found.
- Constipation: telotristat reduces bowel movement frequency; monitor for constipation and re-evaluate therapy if it develops.
- Depressive disorders: depression, depressed mood and decreased interest reported; patients should report symptoms.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (12)
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
- Prasugrel + Telotristat etiprate Moderate
- Simvastatin + Telotristat etiprate Moderate
- Sodium valproate + Telotristat etiprate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
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- Pharmacokinetics
- Patient counselling points
- Food interactions
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Domande frequenti
What is Telotristat etiprate used for?
Telotristat etiprate is a medicine in the class gastrointestinal tract. It is used for Diarrhea.
What side effects have been reported with Telotristat etiprate?
Abdominal pain, Gamma-glutamyl transferase increased, Fatigue, Abdominal distension, Flatulence, Constipation.
Can Telotristat etiprate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. No fetal effects in rats at 9 times human exposure; in rabbits fetal loss only with maternal toxicity (15 times), and more early pup deaths in rats at 5 times. EU: not recommended in pregnancy or without contraception. Avoid; use adequate contraception. Breastfeeding: Unknown. No human or animal milk data; no LactMed record. EU label: should not be used while breastfeeding (risk cannot be excluded); US label: weigh benefits and watch the infant for constipation. Avoid if possible.
What does Telotristat etiprate interact with?
MediHelp lists 12 known interactions for Telotristat etiprate. Moderate: 10 · Minor: 2. The most serious include Bupropion, Capecitabine, Everolimus.
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