Interazioni tra farmaci
Capecitabine + Telotristat etiprate
Gravità: Moderata
Capecitabine and Telotristat etiprate: moderate interaction.
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Sintesi
Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
Cosa significa questa interazione in parole semplici
Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
Perché avviene
Possible modulation of CES2-mediated metabolism of capecitabine; the effect has not been clearly established clinically.
Cosa fare
Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Telotristat etiprate
- Bupropion + Telotristat etiprate Moderata
- Everolimus + Telotristat etiprate Moderata
- Flutamide + Telotristat etiprate Moderata
- Irinotecan + Telotristat etiprate Moderata
- Midazolam + Telotristat etiprate Moderata
- Octreotide + Telotristat etiprate Moderata
Altre interazioni di Capecitabine
Domande frequenti
Can I take Capecitabine with Telotristat etiprate?
MediHelp rates the interaction as moderate. Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
How serious is the interaction between Capecitabine and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
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