Riferimento farmaci
Temoporfin
Temoporfin is a medicine in the class oncology. It is used for head & neck cancer.
- Classe del farmaco: Oncology
- Indicato per: head & neck cancer
Ultimo aggiornamento Fonti: EMA SmPC
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In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01XD05
- Interazioni note
- 1 (Moderata: 1)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Photosensitising agent for photodynamic therapy. Photoactivation with non-thermal light at 652 nm after intravenous administration generates highly reactive oxygen species through interaction of temoporfin with light and oxygen.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Repeat course: a second course may be given at the physician's discretion, with a minimum interval of 4 weeks between treatments
Gravidanza e allattamento
- Gravidanza
- Unsafe No human data; animal studies showed reproductive toxicity. Do not use in pregnancy unless clinically required. Use effective contraception during and up to 3 months after treatment.
- Allattamento
- Unsafe Unknown whether excreted in human milk; risk to infants cannot be excluded. Discontinue breast-feeding for at least one month after injection.
Effetti indesiderati segnalati
- Haemorrhage
- Constipation
- Dysphagia
- Necrotising stomatitis
- Pain in the photoactivated area
- Injection site pain
Controindicazioni
- Hypersensitivity to the active substance or excipients
- Porphyria or other diseases exacerbated by light
- Hypersensitivity to porphyrins
Chi deve prestare attenzione
- All patients become temporarily photosensitive; avoid direct sunlight and bright indoor light for the first 15 days. UV sunscreens give no protection.
- Local photoactivation toxicity may damage surrounding tissue, causing fistula, perforation, vascular rupture, infection and sepsis; shield normal tissue.
- Prevent extravasation; if it occurs, protect the area from light for at least 3 months
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (1)
- Fluorouracil + Temoporfin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Temoporfin used for?
Temoporfin is a medicine in the class oncology. It is used for Head & neck cancer, Squamous cell carcinoma.
What side effects have been reported with Temoporfin?
Haemorrhage, Constipation, Dysphagia, Necrotising stomatitis, Pain in the photoactivated area, Injection site pain.
Can Temoporfin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data; animal studies showed reproductive toxicity. Do not use in pregnancy unless clinically required. Use effective contraception during and up to 3 months after treatment. Breastfeeding: Unsafe. Unknown whether excreted in human milk; risk to infants cannot be excluded. Discontinue breast-feeding for at least one month after injection.
What does Temoporfin interact with?
MediHelp lists 1 known interactions for Temoporfin. Moderate: 1. The most serious include Fluorouracil.
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