Riferimento farmaci
Tranexamic acid
Tranexamic acid is a medicine in the class cardiovascular. It is used for hemorrhage.
- Classe del farmaco: Cardiovascular
- Indicato per: hemorrhage
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Cardiovascular
- Forme farmaceutiche comuni
- iniezione, compressa
- Dosaggi comuni
- 500 mg, 500 mg/5 ml, 100 mg/ml
- Interazioni note
- 16 (Controindicata: 6 · Maggiore: 7 · Moderata: 3)
- Nomi commerciali
- 37
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Antifibrinolytic; synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Menorrhagia: 1300 mg PO TID for up to 5 days during menstruation
Gravidanza e allattamento
- Gravidanza
- Safe Crosses the placenta. Use in the 2nd and 3rd trimesters and at delivery has not shown clear harm, and it is widely used for bleeding after birth (WHO). Rare fatal fetal abnormalities after 1st-trimester use, with confounders. No harm in animals. Use when needed for bleeding, not for heavy periods.
- Allattamento
- Safe Passes into milk in low amounts. US/UK labels: no final assessment; weigh benefits. LactMed: expert opinion considers that breastfeeding should be permitted when the mother needs tranexamic acid.
Effetti indesiderati segnalati
- Headache
- Nausea
- Back pain
- Nasal and sinus symptoms
- Visual abnormalities
Chi deve prestare attenzione
- May cause cerebral edema and cerebral infarction in women with subarachnoid hemorrhage
- Severe allergic reaction reported; anaphylactic shock reported with IV product
- Concurrent use with tretinoin may exacerbate procoagulant effects
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (16)
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
- Alteplase + Tranexamic acid Major
- Anti-inhibitor coagulant complex + Tranexamic acid Major
- Factor ix + Tranexamic acid Major
- Factor ix complex + Tranexamic acid Major
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- Paediatric dosing
- Patient counselling points
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Altri farmaci della stessa classe
Domande frequenti
What is Tranexamic acid used for?
Tranexamic acid is a medicine in the class cardiovascular. It is used for Hemorrhage, Melasma, Menorrhagia, Uterine fibroids.
What side effects have been reported with Tranexamic acid?
Headache, Nausea, Back pain, Nasal and sinus symptoms, Visual abnormalities.
Can Tranexamic acid be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Crosses the placenta. Use in the 2nd and 3rd trimesters and at delivery has not shown clear harm, and it is widely used for bleeding after birth (WHO). Rare fatal fetal abnormalities after 1st-trimester use, with confounders. No harm in animals. Use when needed for bleeding, not for heavy periods. Breastfeeding: Safe. Passes into milk in low amounts. US/UK labels: no final assessment; weigh benefits. LactMed: expert opinion considers that breastfeeding should be permitted when the mother needs tranexamic acid.
What does Tranexamic acid interact with?
MediHelp lists 16 known interactions for Tranexamic acid. Contraindicated: 6 · Major: 7 · Moderate: 3. The most serious include Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel.
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