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Ethinyl estradiol-levonorgestrel + Tranexamic acid

Gravità: Controindicata

Ethinyl estradiol-levonorgestrel and Tranexamic acid: contraindicated interaction.

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Sintesi

Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.

Cosa significa questa interazione in parole semplici

Ethinyl estradiol-levonorgestrel and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ethinyl estradiol-levonorgestrel belongs to Endocrine; Tranexamic acid belongs to Cardiovascular.

Livello di evidenza: Moderate

Perché avviene

Additive prothrombotic effects from estrogen-induced coagulation changes and antifibrinolysis.

Cosa fare

Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Ethinyl estradiol-levonorgestrel with Tranexamic acid?

MediHelp rates the interaction as contraindicated. Ethinyl estradiol-levonorgestrel and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.

How serious is the interaction between Ethinyl estradiol-levonorgestrel and Tranexamic acid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.

What other medicines interact with Ethinyl estradiol-levonorgestrel?

MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Aminocaproic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.

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